I explore three points about the relationship between C.I. Lewis’s conceptual pragmatism and W.V. Quine’s naturalized epistemology inspired by Robert Sinclair’s Quine, Conceptual Pragmatism, and the Analytic-Synthetic Distinction. First, I highlight Lewis’s long-standing commitment to Platonism about meaning and its connection to his reflective philosophical method and rejection of a linguistic account of analyticity. Second, I consider Sinclair’s claim that “Lewis’s epistemology provides no indication concerning how, despite different sensory experiences, we still come to agree on what we are talking about and what counts as evidence” (2022, 113). I find more hints, especially in Lewis’s account of how we verify that two people share meaning in common. However, some of the pragmatic and broadly empirical factors Lewis appeals to are not part of Quine’s naturalized epistemology. Finally, I relate these points to Quine’s (1953/1980) claim to advance a more “thorough pragmatism” than Lewis. Quine does not say much about action, value, and ethics, but these are central parts of Lewis’s conceptual pragmatism and a source of his reluctance to abandon those parts of his epistemology that Sinclair argues Quine found dispensable.